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Activated from the antibiotic rifampicin and many plant metabolites, for example hyperforin, guggulipid, colupulone, and isoflavones. Reaction to distinct ligands is species-unique. Activated by In a natural way happening steroids, like pregnenolone and progesterone. Binds into a response factor in the promoters with the CYP3A4 and ABCB1/MDR1 genes

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